Researchers at Harvard and Princeton universities have taken a crucial step toward building biological computers, tiny implantable devices that can monitor the activities and characteristics of human cells. The information provided by these “molecular doctors,” constructed entirely of DNA, RNA, and proteins, could eventually revolutionize medicine by directing therapies only to diseased cells or tissues.The results will be published this week in the journal Nature Biotechnology.“Each human cell already has all of the tools required to build these biocomputers on its own,” says Harvard’s Yaakov “Kobi” Benenson, a Bauer Fellow in the Faculty of Arts and Sciences’ Center for Systems Biology. “All that must be provided is a genetic blueprint of the machine and our own biology will do the rest. Your cells will literally build these biocomputers for you.”Evaluating Boolean logic equations inside cells, these molecular automata will detect anything from the presence of a mutated gene to the activity of genes within the cell. The biocomputers’ “input” is RNA, proteins and chemicals found in the cytoplasm; “output” molecules indicating the presence of the telltale signals are easily discernable with basic laboratory equipment.“Currently, we have no tools for reading cellular signals,” Benenson says. “These biocomputers can translate complex cellular signatures, such as activities of multiple genes, into a readily observed output. They can even be programmed to automatically translate that output into a concrete action, meaning they could either be used to label a cell for a clinician to treat or they could trigger therapeutic action themselves.”Benenson and his colleagues demonstrate in their Nature Biotechnology paper that biocomputers can work in human kidney cells in a culture. Research into the system’s ability to monitor and interact with intracellular cues such as mutations and abnormal gene levels is still in progress.Benenson and colleagues, including Ron Weiss, associate professor of electrical engineering at Princeton, have also developed a conceptual framework by which various phenotypes could be represented logically.A biocomputer’s calculations, while mathematically simple, could allow researchers to build biosensors or medicine delivery systems capable of singling out very specific types or groups of cells in the human body. Molecular automata could allow doctors to specifically target only cancerous or diseased cells via a sophisticated integration of intracellular disease signals, leaving healthy cells completely unaffected.Benenson and Weiss worked in collaboration with undergraduate Keller Rinaudo, postdoctoral researcher Leonidas Bleris, and summer intern Rohan Maddamsetti, all at Harvard, and with Sairam Subramanian, a graduate student at Princeton. Their research is supported by Harvard University and a center grant from the National Institute of General Medical Sciences.
William Byron got a phone call from team owner Rick Hendrick three weeks ago asking if he felt ready to move up into the Monster Energy NASCAR Cup Series.This past weekend, Byron got another call from the boss, again with more good news.“He asked me what my thoughts were about driving the No. 24,” Byron told NASCAR.com Tuesday. “I was just ecstatic, just to know that I’m going to have that number and the history there.”RELATED: No. 24 car through the yearsHendrick Motorsports officials announced Tuesday evening that Byron will compete in the No. 24 Chevrolet in 2018, when he is scheduled to make his Monster Energy NASCAR Cup Series debut.Meanwhile teammate Chase Elliott, who currently drives the No. 24, will begin competing in the No. 9.“For Chase to be in the No. 9 is really cool,” said Byron, who currently competes in the NASCAR XFINITY Series for JR Motorsports. “I raced Chase in a Late Model race a few years back and remember how cool it was to race again him. Now we’re teammates and working side-by-side and both have those numbers that mean a lot.”Byron was initially scheduled to take over the No. 5 Chevrolet currently driven by Kasey Kahne. That number will not be used by the organization in 2018, however.The No. 24 has been used in NASCAR as far back as 1950, the second year of the series’ existence. But it wasn’t until the mid-90s and the arrival of a fresh-faced Jeff Gordon that the car number began turning up in Victory Lane.For 20 of the 23 years he competed full time, Gordon parked the No. 24 in Victory Lane on what would often seem a regular basis, winning 93 races, four championships and 81 poles.RELATED: Fast facts on iconic numbers“It’s really special for me just because of how much it means to Hendrick Motorsports and the legacy that Jeff Gordon and everybody on that team left behind,” Byron, 19, said. “It’s a really neat connection for me, something that I will take a lot of pride in running the number and hopefully be able to make my own name with it and be able to keep the legacy alive.”Elliott ascended to the No. 24 ride when Gordon stepped aside following the 2015 season and has done remarkably well with the team, finishing 10th or better in nearly one-half his career starts. He has 16 top-five and three second-place finishes.The No. 9, however, carries much Elliott heritage. Chase’s father, Bill, scored 38 of his 44 career wins in the No. 9, as well as the 1988 series championship.RELATED: Classic images of the No. 9According to Hendrick officials, personnel will remain with their respective teams — the current No. 24 crew will remain intact but the car number will now be No. 9; likewise, those with the No. 5 currently will be fielding the No. 24 next year instead.“It’s such an honor to take over that number,” Byron said. “It’s something I never would have imagined. It’s an honor and it’s something I really look forward to. I know there’s been a lot of success behind (it). … I was looking at Jeff’s stats and it’s incredible what he did with it.”In a release from the team, Elliott said he “wasn’t sure if I’d ever drive the (No.) 9 again.”“It’s a huge deal to my family and everyone back home (in Georgia),” he said, “and I hope all of our fans will be pumped to see it back on the race track. There’s a legacy attached to that number, and I want to carry it on. I think it’s awesome that Hendrick Motorsports and NAPA wanted to do this. It’s impossible not to be excited.”Elliott won the 2014 XFINITY Series championship driving the No. 9 Chevrolet for JR Motorsports. This year, Byron has three wins and is currently second in the points standings with the No. 9 team.Byron said the No. 9 “really started with Chase” at JRM.“It’s been a good number for me but … it’s not a number I would want to have in the Cup Series. I think it’s always belonged to the Elliotts and it’s something that’s special to them.“I’m really looking forward to the 24 and I think it’s a new chapter for me and something I’m really excited about.”Hendrick Motorsports also fields the No. 48 of seven-time series champion Jimmie Johnson and the No. 88 of Dale Earnhardt Jr. Earnhardt will step down from full-time competition in the Monster Energy Series at the end of the 2017 season and will be replaced by 24-year-old Alex Bowman.Hendrick, who formed All-Star Racing, the forerunner to Hendrick Motorsports, in 1984, knows much of the history of NASCAR and said he knows what the No. 9 has meant to the Elliott family through the years.“They’ve contributed so much to our sport,” Hendrick said, “and I’m happy we can honor that history by bringing the number back.”There is a stipulation, however.“I told Chase we’d only do it if he promised to win a bunch of races, so I’m going to hold him to that,” Hendrick said.Putting Bryon in the No. 24, he said, was more of a “fit factor.”“And that’s what I see with William and our organization,” Hendrick said. “He reminds me a lot of Jeff at that age with regard to being a special talent and having a great head on his shoulders.“But William is also his own person with his own career ahead of him. It’s going to be fun to watch him jump in the 24 and show what he’s capable of.”Not running a No. 5 entry was “by far the hardest part” of the car number decision,” according to Hendrick. Geoff Bodine won the organization’s first race in the No. 5 in ’84 and Terry Labonte won a championship with the car number in 1996.“The memories and the history will always be there,” he said, “and I won’t rule out bringing it back some day. Never say never.”
vtdigger.org April 30, 2012 It is finished. Today, the House of Representatives has approved the final reapportionment map that sets the boundaries for the new districts for the decade to come. The vote was 124-8, in favor.Of the 104 districts, 50 were not changed, according to Rep. Donna Sweaney, D-Windsor, and chair of the Government Operations Committee, which led the effort. The deviation rate is about 18 percent for the House map.The House, with a few changes, readopted the map it had previously approved before the Senate proposed major adjustments that were ultimately rejected in conference committee.The year and a half long effort was marked by civility, tripartisan input and a conscious attempt at fairness and nonpartisanship on the part of the majority Democrats who led the process in the Legislature.â This is the second time Iâ ve been involved in redistricting,’Sweaney said. The effort, unlike the more contentious 2002 redistricting process, was constructive and it was conducted in an â open and transparent setting,’she said.â We wanted to make a political exercise as nonpolitical and fair as possible,’Sweaney said. â Granted these maps may not make everyone happy.âSweaney then quoted a â wise’lawmaker who once said: â Itâ s a real honor for me to represent the fine citizens of Vermont, no matter where I live.âNot everyone was happy. A handful of members were directly affected by the changes voted against the reapportionment bill.Rep. Cynthia Browning, D-Arlington, said her single-member district was in compliance already and didnâ t need to be changed. Browning will now be part of a two-seat district with Rep. Jeff Wilson, D-Manchester.â Itâ s never been about me or what I wanted,’Browning said. â It was about speaking for my towns and what they wanted. I deeply regret not succeeding as an advocate on their behalf.âIn order to give Burlington an additional House seat, the lines were redrawn to pull Mount Holly, Shrewsbury and Ludlow into a single-member district. As a result, Republican Dennis Devereux and Democrat Eldred French will go head to head this election. vtdigger.org April 30, 2012
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The “FIFA agent” is the go-to man for the Italian press when they want a comment regarding transfers, and it’s led to some bold (and not so bold) assertions.A lot of them came during the Simone Zaza at West Ham debacle, but he’s also come out with stuff like ‘Wayne Rooney was offered to Napoli’ and claims he was involved in a potential €90m Pierre-Emerick Aubameyang to Arsenal deal back in 2016.Either way, we wouldn’t call him the most reliable source of information when it comes to transfers.Embed from Getty ImagesWe say all this because Morabito recently had a chat with RMC Sport (an Italian radio station, not the French one) where he discussed Felipe Anderson to West Ham.He said, relayed by TuttoMercatoWeb: “West Ham-Felipe Anderson won’t get done. The request of €40m is too high and the English, who offered €35m, will move onto other targets. I recommend West Ham to give up on Felipe Anderson: Lotito is impossible as a representative.”Given the Italian media were this morning reporting of talks still ongoing between the two sides with Jordan Lukaku also a target, this seems a little off.The fact that he’s recommending West Ham to step away suggests they haven’t done that just yet.Bottom line: we wouldn’t take this as gospel. At all.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksTrending TodayForge of Empires – Free Online GameIf You Like to Play, this City-Building Game is a Must-Have. No Install.Forge of Empires – Free Online GameUndoRaid: Shadow Legends | Free DownloadEven Non-Gamers Are Obsessed With This RPG Game (It’s Worth Installing!)Raid: Shadow Legends | Free DownloadUndoDash Living Hong KongExpat’s Favorite – Fully Serviced Studio from HK$10,000 / moDash Living Hong KongUndo聽多多 Hearmore.asia1969年前出生的香港居民現可免費試戴頂尖的歐洲助聽器聽多多 Hearmore.asiaUndoDating.comWhere do attractive singles meet in Tung Chung?Dating.comUndoStanChart by CNBC CatalystDigitization in Banks Is No Longer About Efficiency, but Business Resilience. Don’t Get Left Behind.StanChart by CNBC CatalystUndoInstant Voice TranslatorGenius Japanese Invention Allows You To Instantly Speak 43 LanguagesInstant Voice TranslatorUndoCNBC InternationalHere’s How Big Businesses in Singapore Are Managing the Impact of COVID-19.CNBC InternationalUndoCNN with DBS BankThe New Role Banks Are PlayingCNN with DBS BankUndo It’s been a while since we’ve covered something Vincenzo Morabito has said, and there’s a reason for that.